Signaling pathways that regulate blood vessel morphogenesis

Signaling pathways that regulate cell division.

Cell division requires careful orchestration of three major events: entry into mitosis, chromosomal segregation, and cytokinesis. Signaling within and between the molecules that control these events allows for their coordination via checkpoints, a specific class of signaling pathways that ensure the dependency of cell-cycle events on the successful completion of preceding events. Multiple posit...

Enzymatic pathways that regulate endocannabinoid signaling in the nervous system.

Chemical signals, or neurotransmitters, represent the fundamental mode for intercellular communication in the nervous system. The classical model for neurotransmitter action involves the uptake and storage of these small molecules into synaptic vesicles, release of vesicular contents into the synaptic cleft in response to depolarization of the presynaptic terminal by an action potential, bindin...

Signaling Pathways that Regulate Autophagic Muscle Protein Degradation in C

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Fibrillin microfibrils: connective tissue pathways that regulate shape and signaling.

Neurovascular development uses VEGF-A signaling to regulate blood vessel ingression into the neural tube.

Neurovascular development requires communication between two developing organs, the neuroepithelium and embryonic blood vessels. We investigated the role of VEGF-A signaling in the embryonic crosstalk required for ingression of angiogenic vessel sprouts into the developing neural tube. As the neural tube develops, blood vessels enter at specific points medially and ventrally from the surroundin...